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Metastatic Cancer


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On This Page


   What Is Metastatic Cancer?

   How Cancer Spreads

   Where Cancer Spreads

   Symptoms of Metastatic Cancer

   Treatment for Metastatic Cancer

   When Metastatic Cancer Can No Longer Be Controlled

   Ongoing Research


Metastasis; drawing shows primary cancer that has spread from the colon to other parts of the body (the lung and the brain). An inset shows cancer cells spreading from the primary cancer, through the blood and lymph system, to another part of the body where a metastatic tumor has formed.



In metastasis, cancer cells break away from where they first formed (primary cancer), travel through the blood or lymph system, and form new tumors (metastatic tumors) in other parts of the body. The metastatic tumor is the same type of cancer as the primary tumor.

What Is Metastatic Cancer?


The main reason that cancer is so serious is its ability to spread in the body. Cancer cells can spread locally by moving into nearby normal tissue. Cancer can also spread regionally, to nearby lymph nodes, tissues, or organs. And it can spread to distant parts of the body. When this happens, it is called metastatic cancer. For many types of cancer, it is also called stage IV (four) cancer. The process by which cancer cells spread to other parts of the body is called metastasis.


When observed under a microscope and tested in other ways, metastatic cancer cells have features like that of the primary cancer and not like the cells in the place where the cancer is found. This is how doctors can tell that it is cancer that has spread from another part of the body.


Metastatic cancer has the same name as the primary cancer. For example, breast cancer that spreads to the lung is called metastatic breast cancer, not lung cancer. It is treated as stage IV breast cancer, not as lung cancer.

Sometimes when people are diagnosed with metastatic cancer, doctors cannot tell where it started. This type of cancer is called cancer of unknown primary origin, or CUP. See the Carcinoma of Unknown Primary page for more information.

When a new primary cancer occurs in a person with a history of cancer, it is known as a second primary cancer. Second primary cancers are rare. Most of the time, when someone who has had cancer has cancer again, it means the first primary cancer has returned.

How Cancer Spreads

Metastasis: How Cancer Spreads

Metastasis: How Cancer Spreads

During metastasis, cancer cells spread from the place in the body where they first formed to other parts of the body.

Cancer cells spread through the body in a series of steps. These steps include:

   Growing into, or invading, nearby normal tissue

   Moving through the walls of nearby lymph nodes or blood vessels

   Traveling through the lymphatic system and bloodstream to other parts of the body

   Stopping in small blood vessels at a distant location, invading the blood vessel walls, and moving into the surrounding tissue

   Growing in this tissue until a tiny tumor forms

   Causing new blood vessels to grow, which creates a blood supply that allows the tumor to continue growing

Most of the time, spreading cancer cells die at some point in this process. But, as long as conditions are favorable for the cancer cells at every step, some of them are able to form new tumors in other parts of the body. Metastatic cancer cells can also remain inactive at a distant site for many years before they begin to grow again, if at all.

Where Cancer Spreads

Cancer can spread to most any part of the body, although different types of cancer are more likely to spread to certain areas than others. The most common sites where cancer spreads are the bone, liver, and lung. The following list shows the most common sites of metastasis, not including the lymph nodes, for some common cancers:

Common Sites of Metastasis

Cancer Type Main Sites of Metastasis

Bladder Bone, liver, lung

Breast Bone, brain, liver, lung

Colon Liver, lung, peritoneum

Kidney Adrenal gland, bone, brain, liver, lung

Lung Adrenal gland, bone, brain, liver, other lung

Melanoma Bone, brain, liver, lung, skin, muscle

Ovary Liver, lung, peritoneum

Pancreas Liver, lung, peritoneum

Prostate Adrenal gland, bone, liver, lung

Rectal Liver, lung, peritoneum

Stomach Liver, lung, peritoneum

Thyroid Bone, liver, lung

Uterus Bone, liver, lung, peritoneum, vagina

Symptoms of Metastatic Cancer

Metastatic cancer does not always cause symptoms. When symptoms do occur, their nature and frequency will depend on the size and location of the metastatic tumors. Some common signs of metastatic cancer include:

   Pain and fractures, when cancer has spread to the bone

   Headache, seizures, or dizziness, when cancer has spread to the brain

   Shortness of breath, when cancer has spread to the lung

   Jaundice or swelling in the belly, when cancer has spread to the liver

Treatment for Metastatic Cancer

Once cancer spreads, it can be hard to control. Although some types of metastatic cancer can be cured with current treatments, most cannot. Even so, there are treatments for all patients with metastatic cancer. The goal of these treatments is to stop or slow the growth of the cancer or to relieve symptoms caused by it. In some cases, treatments for metastatic cancer may help prolong life.

The treatment that you may have depends on your type of primary cancer, where it has spread, treatments you’ve had in the past, and your general health. To learn about treatment options, including clinical trials, find your type of cancer among the PDQ® Cancer Information Summaries for Adult Treatment and Pediatric Treatment.

When Metastatic Cancer Can No Longer Be Controlled

If you have been told you have metastatic cancer that can no longer be controlled, you and your loved ones may want to discuss end-of-life care. Even if you choose to continue receiving treatment to try to shrink the cancer or control its growth, you can always receive palliative care to control the symptoms of cancer and the side effects of treatment. Information on coping with and planning for end-of-life care is available in the Advanced Cancer section.

Ongoing Research

Researchers are studying new ways to kill or stop the growth of primary and metastatic cancer cells. This research includes finding ways to help your immune system fight cancer. Researchers are also trying to find ways to disrupt the steps in the process that allow cancer cells to spread. Visit the Metastatic Cancer Research page to stay informed of ongoing research funded by NCI.

Related Resources

   Advanced Cancer

   Coping with Advanced Cancer

   Updated: February 6, 2017

Most text on the National Cancer Institute website may be reproduced or reused freely. The National Cancer Institute should be credited as the source and a link to this page included, e.g., “Metastatic Cancer was originally published by the National Cancer Institute.”

Please note that blog posts that are written by individuals from outside the government may be owned by the writer, and graphics may be owned by their creator. In such cases, it is necessary to contact the writer, artists, or publisher to obtain permission for reuse.

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Understanding Advanced Cancer, Metastatic Cancer, and Bone Metastasis

What is advanced cancer?

Different health care providers may not mean the exact same thing when they use the term advanced cancer. Here, when we refer to advanced cancer, we’re talking about cancers that cannot be cured. This means cancers that won’t go away and stay away completely with treatment.

Advanced cancers can be locally advanced or metastatic. (Metastatic cancers have spread from where they started to other parts of the body and are covered in the next section.) Cancers that have spread are often considered advanced when they can’t be cured or controlled with treatment. But not all advanced cancers have spread to other parts of the body. For example, some cancers that start in the brain may be considered advanced because of their large size or closeness to important organs or blood vessels. This can make them life-threatening even though they haven’t spread to other parts of the body. In the same way, not all metastatic cancers are advanced cancers. Some cancers, such as testicular cancer, can spread to other parts of the body and still be very curable.

Locally advanced cancer is used to describe cancer that has grown outside the organ it started in but has not yet spread to distant parts of the body. For example, locally advanced pancreatic cancer is often not curable. But other locally advanced cancers, such as some prostate cancers, may be cured.

If you or a loved one is told that you have advanced cancer, it’s very important to find out exactly what the doctor means. Some may use the term to describe metastatic cancer, while others might use it in other situations. Be sure you understand what the doctor is talking about and what it means for you.

Advanced cancer can often be treated. Even if the cancer can’t be cured, treatment can sometimes:

   Shrink the cancer

   Slow its growth

   Help relieve symptoms

   Help you live longer

For some people, the cancer may already be advanced when they first learn they have the disease. For others, the cancer may not become advanced until years after it was first diagnosed.

As advanced cancer grows, it can cause symptoms that may need to be treated to help control them. These symptoms can almost always be treated, even when the cancer itself no longer responds to treatment.

What is metastatic cancer?

Metastatic cancer is a cancer that has spread from the part of the body where it started (the primary site) to other parts of the body. When cancer cells break away from a tumor, they can travel to other parts of the body through the bloodstream or the lymph system. (Lymph vessels are much like blood vessels, except they carry a clear fluid and immune system cells.)

This image shows some parts of the lymph system, like lymph nodes and lymph vessels, as well as organs and tissues that contain many lymphocytes (immune cells).

color diagram showing the lymphatic system in the human body (location of lymph nodes, lymphatic vessels)/also shows the location of the thymus, spleen, bone marrow, stomach, colon and small intestine

If the cells travel through the lymph system, they could end up in nearby lymph nodes (small, bean-sized collections of immune cells) or they could spread to other organs. More often, cancer cells that break off from the main tumor travel through the bloodstream. Once in the blood, they can go to any part of the body. Many of these cells die, but some may settle in a new area, start to grow, and form new tumors. This spread of cancer to a new part of the body is called metastasis.

Cancer cells have to go through several steps to spread to new parts of the body:

   They have to be able to break away from the original tumor and enter the bloodstream or lymph system, which can carry them to another part of the body.

   They need to attach to the wall of a blood or lymph vessel and move through it into a new organ.

   They need to be able to grow and thrive in their new location.

   They need to be able to avoid attacks from the body’s immune system.

Going through all these steps means the cells that start new tumors may no longer be exactly the same as the ones in the tumor they started in. This might make them harder to treat.

Even when cancer has spread to a new area, it’s still named after the part of the body where it started. For instance, breast cancer that has spread to the lungs is called “metastatic breast cancer to the lungs” – it’s not lung cancer. Treatment is also based on where the cancer started. If prostate cancer spreads to the bones, it’s still prostate cancer (not bone cancer), and the doctor will recommend treatments that have been shown to help against metastatic prostate cancer. Likewise, colon cancer that has spread to the liver is treated as metastatic colon cancer, not liver cancer.

Sometimes the metastatic tumors have already begun to grow when the cancer is first found and diagnosed. And in some cases, a metastasis may be found before the original (primary) tumor is found. If a cancer has already spread to many places when it’s found, it may be very hard to figure out where it started. If this happens the cancer is called cancer of unknown primary.

Why cancer cells tend to spread to certain parts of the body

Where a cancer starts is linked to where it will spread. Most cancer cells that break free from the original tumor are carried in the blood or lymph system until they get trapped in the next “downstream” organ or set of lymph nodes. Once the cells are there, they can start to grow and form new tumors. This explains why breast cancer often spreads to underarm lymph nodes, but rarely to lymph nodes in the groin. Likewise, there are many cancers that commonly spread to the lungs. This is because the heart pumps blood from the rest of the body through the lungs’ blood vessels before sending it elsewhere.

What is bone metastasis?

A bone metastasis is an area of bone that contains cancer that spread there from somewhere else.

Cancer can spread to any bone in the body, but metastases are most often found in bones near the center of the body. The spine is the most common site. Other common sites are the hip bone (pelvis), upper leg bone (femur), upper arm bone (humerus), ribs, and the skull.

Once cancer has spread to the bones or to other parts of the body it’s rarely able to be cured. Still, it often can be treated to shrink, stop, or slow its growth. Even if a cure is no longer possible, treating the cancer may be able to help you live longer and feel better.

How does bone metastasis cause bone changes and other problems?

Bone is the supporting framework of the body. Bones are made of a network of fibrous tissue called matrix, minerals such as calcium that attach to the matrix and give the bone its strength and hardness, and 2 main kinds of bone cells are osteoblasts and osteoclasts.


Knowing a little about these 2 kinds of cells can help you understand how bone metastases grow, and how some medicines work to treat bone metastases. The osteoblast is the cell that forms new bone, and the osteoclast is the cell that dissolves old bone. When these cells are both working right, new bone is always forming while old bone is dissolving. This helps keep the bones strong.

Cancer cells can affect the bones by interfering with osteoblasts and osteoclasts:


   Often, the cancer cells make substances that turn on the osteoclasts. This leads to bone being broken down without new bone being made. This weakens the bones. The holes that develop when parts of bones dissolve are called osteolytic or lytic lesions. Lytic lesions are so weak that they can cause the bone to easily break.

   Sometimes, the cancer cells release substances that turn on the osteoblasts. This leads to new bone being made without breaking down the old bone broken down first. This makes areas of the bones harder, a condition called sclerosis. The areas of bone where this occurs are called osteoblastic or blastic lesions. Although these blastic areas are harder, the structure of the bone is not normal and these areas actually break more easily than normal bone.

Bone metastasis can cause other problems as well:

When cancer spreads to the bones of the spine, it can press on the spinal cord. This can cause nerve damage that may even lead to paralysis if not treated.

   As cancer cells damage the bones, calcium from the bones is released into the blood. This can lead to problems caused by high blood calcium levels (hypercalcemia).


Why do cancers metastasize to bones?


For cancer cells to spread to other parts of the body, they have to go through many changes:


   They have to be able to break away from the original (primary) tumor and get into the bloodstream or lymph system, which can carry them to another part of the body.

   At some point they need to attach to the wall of a blood or lymph vessel and move through it, out into a new organ.

   They then need to be able to grow and thrive in their new location.

All the while, the cancer cells need to be able to avoid attacks from the body’s immune system. Going through all these steps means the cells that start new tumors may no longer be exactly the same as the ones in the tumor where they started, but they will still be called the same name. For instance, breast cancer that spreads to the bone is called metastatic breast cancer, not bone cancer.

What’s the difference between primary bone cancer and bone metastasis?


Some cancers start in the bone, rather than spreading to the bones from somewhere else. Cancers that start in the bone are called primary bone cancers. These cancers are very different from bone metastases. Bone metastasis is much more common than primary bone cancers, especially in adults.

Information on different types of primary bone cancers can be found in Bone Cancer, Osteosarcoma, and Ewing Family of Tumors.

Written by


The American Cancer Society medical and editorial content team

Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: December 15, 2016 Last Revised: December 15, 2016

American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.

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Metastasis is the spread of cancer cells to new areas of the body (often by way of the lymph system or bloodstream). A metastatic cancer, or metastatic tumor, is one which has spread from the primary site of origin (where it started) into different area(s) of the body.

Tumors formed from cells that have spread are called secondary tumors. The cancer may have spread to areas near the primary site (regional metastasis), or to parts of the body that are farther away (distant metastasis).

Diagnosing metastatic cancer

Cancer that has spread from the primary (original) site to other places in the body is generally classified as advanced. When the cancer has spread only to nearby tissues or lymph nodes, it is called locally advanced cancer. When the cancer has spread to other parts of the body, it is called metastatic cancer. The liver, lungs, lymph nodes, and bones are common areas of spread or metastasis.

Even when cancer spreads to a new location, it is still named after the area of the body where it started. For example, a person with breast cancer that has spread to the bones is said to have breast cancer with bone metastases. If a cancer has spread widely throughout the body before it is discovered and it is unknown exactly where it started, it is called cancer of unknown primary origin.


Learn more about diagnosing cancer

Treatment for metastatic cancer

Treatment for metastatic cancer aims to slow the growth or spread of the cancer. Treatment depends on the type of cancer, where it started, the size and location of the metastasis, and other factors.

Typically, metastatic cancer requires systemic therapy, or medications given by mouth or injected into the bloodstream to reach cancer cells throughout the body, such as chemotherapy or hormone therapy. Other treatments may include biological therapy, radiation therapy, surgery, or a combination of these.

Even if the cancer has stopped responding to treatment, many therapies can ease side effects and improve quality of life. Palliative treatments, which may be the same treatments used to treat cancer, aim to relieve symptoms and side effects.

At Cancer Treatment Center of America® (CTCA), we provide personalized treatment plans using advanced technologies to target advanced and complex cancers, combined with integrative oncology services to improve quality of life. We offer specialized treatment programs for cancers that spread to the brain, bone, liver and other areas.

Learn more about how we treat cancer

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